2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[5-(Acetylamino)-6-methylpyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 386026Notes

Reaction equation

HRID 386026 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]([CH3:29])[C:26]([NH:30][C:31](=[O:33])[CH3:32])=[CH:25][CH:24]=1>>[C:31]([NH:30][C:26]1[CH:25]=[CH:24][C:23]([NH:1][C:2]2[S:3][C:4]([C:10]3[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=3[F:16])=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])=[N:28][C:27]=1[CH3:29])(=[O:33])[CH3:32]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525698N-(6-chloro-2-methylpyridin-3-yl)acetamide

Product 1

HCID 595257512-{[5-(Acetylamino)-6-methylpyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and N-(6-chloro-2-methylpyridin-3-yl)acetamide (89 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-dffb214a836940cfbbf19d9fbcd5d851
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…