2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525749, compound

HRID 386030Notes

Reaction equation

HRID 386030 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].[CH:22]1([CH2:25][NH:26][C:27]2[C:28]([CH3:33])=[N:29][CH:30]=[CH:31][CH:32]=2)[CH2:24][CH2:23]1>>[CH:22]1([CH2:25][NH:26][C:27]2[CH:32]=[CH:31][C:30]([NH:1][C:2]3[S:3][C:4]([C:10]4[C:11]([F:21])=[CH:12][C:13]([C:17]([OH:20])([CH3:18])[CH3:19])=[CH:14][C:15]=4[F:16])=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])=[N:29][C:28]=2[CH3:33])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 68671139HCID 68671139, compound

Product 1

HCID 59525749HCID 59525749, compound

Procedure

The title compound was prepared in the same manner described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and N-(cyclopropylmethyl)-2-methylpyridin-3-amine (94 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-8e4de174b0634fe2990863c8d892ca16
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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