2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was synthesized from 1-[(6-bromopyridin-2-yl)methyl]-4-methyl-1,4-azaphosphinane 4-oxide (121 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.

Provenance & Evidence