2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525689, compound

HRID 386038Notes

Reaction equation

HRID 386038 reaction equation
[CH3:1][O:2][P:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9](Br)[N:8]=1)([CH3:5])=[O:4].[NH2:14][C:15]1[S:16][C:17]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:25][C:24]=2[F:33])=[CH:18][C:19]=1[C:20]([NH2:22])=[O:21]>>[CH3:1][O:2][P:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:14][C:15]2[S:16][C:17]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([OH:32])([CH3:30])[CH3:31])=[CH:25][C:24]=3[F:33])=[CH:18][C:19]=2[C:20]([NH2:22])=[O:21])[N:8]=1)([CH3:5])=[O:4]

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526266HCID 59526266, compound

Product 1

HCID 59525689HCID 59525689, compound

Procedure

The title compound was synthesized from methyl[(6-bromopyridin-2-yl)methyl]methylphosphinate (90 mg, 0.34 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.34 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-74ea098ca0e44df2acac9da1408e1f78
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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