Methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-4-carboxylate → Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylate
Reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[C:32]([F:33])=[CH:31][C:30]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:29][C:28]=2[F:38])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[NH2:26][C:24]([C:23]1[CH:22]=[C:21]([C:27]2[C:32]([F:33])=[CH:31][C:30]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:29][C:28]=2[F:38])[S:20][C:19]=1[NH:18][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1)=[O:25]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared as described in Example 1 using methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-4-carboxylate (357 mg, 1.20 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (375 mg, 1.20 mmol) as starting materials.
Sources & evidence
- ORD record
- ord-5c0ce299454a415c8981b6c6acc679e1
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367706B2
Reaction notes
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