HRID386045

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1cc(F)c(-c2cc(C(N)=O)c(N)s2)c(F)c1

HCID59525619

未命名化合物

结构：CC(C)(C)OC(=O)NCc1cn(Cc2cccc(Br)n2)nn1

HCID59526311

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCc1cn(Cc2cccc(Nc3sc(-c4c(F)cc(C(C)(C)O)cc4F)cc3C(N)=O)n2)nn1

HCID59526113

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure in Example 1 using tert-Butyl({1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazol-4-yl}methyl)carbamate (147 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) as the starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3145fded20248a79d519f807747fd98
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][C:9]1[N:10]=[N:11][N:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17](Br)[N:16]=2)[CH:13]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:23][C:24]1[S:25][C:26]([C:32]2[C:37]([F:38])=[CH:36][C:35]([C:39]([OH:42])([CH3:41])[CH3:40])=[CH:34][C:33]=2[F:43])=[CH:27][C:28]=1[C:29]([NH2:31])=[O:30]>>[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][C:9]1[N:10]=[N:11][N:12]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:23][C:24]3[S:25][C:26]([C:32]4[C:33]([F:43])=[CH:34][C:35]([C:39]([OH:42])([CH3:40])[CH3:41])=[CH:36][C:37]=4[F:38])=[CH:27][C:28]=3[C:29]([NH2:31])=[O:30])[N:16]=2)[CH:13]=1)([CH3:4])([CH3:3])[CH3:2]