1,2-Dichloroethane → HCID 59525834, compound

Participants

Reaction Steps

Potassium 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-5-carboxylate (131 mg, 0.24 mmol), HOBT (72.6 mg, 0.47 mmol), EDC (91 mg, 0.47 mmol), and methylamine hydrochloride (48 mg, 0.71 mmol) were combined in DMF (5.0 mL), and DIEA (124 μL, 0.71 mmol) was added. The reaction was stirred at room temperature overnight. The solution was diluted with water. The precipitate was collected by filtration, washed with water and CH2Cl2, and dried to provide the title compound as an off-white solid.

Provenance & Evidence