反应详情

温度

-20 °C

A solution of i-Pr2NH (370 μL, 2.59 mmol) in THF (3.0 mL) was cooled to −20° C., and n-butyllithium (970 μL, 2.43 mmol) was added dropwise. After stirring for 15 minutes at −20° C., the colorless solution was cooled to −78° C. before adding 2-bromo-6-(1H-1,2,3-triazol-1-ylmethyl)pyridine (200 mg, 0.84 mmol) in THF (2.0 mL) dropwise over 30 minutes. After stirring for an additional 30 minutes at −78° C., 1H-benzotriazole-1-methanol (250 mg, 1.67 mmol) in THF (5.0 mL) was added dropwise over 25 minutes. The solution was stirred at −78° C. for 2 h. The reaction was quenched (while cold) with water and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated. Flash chromatography (50-100% EtOAc/hexanes) afforded the title compound as a colorless oil.

1. temperaturethe colorless solution was cooled to −78° C.
2. stirringAfter stirring for an additional 30 minutes at −78° C.
3. stirringThe solution was stirred at −78° C. for 2 h
4. customThe reaction was quenched (while cold) with water
5. extractionextracted with EtOAc (2×)
6. washThe combined organic layers were washed with brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. customevaporated