2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525957, compound

HRID 386053Notes

Reaction equation

HRID 386053 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[N:11]2)=[CH:4][CH:3]=1.[NH2:15][C:16]1[S:17][C:18]([C:24]2[C:29]([F:30])=[CH:28][C:27]([C:31]([OH:34])([CH3:33])[CH3:32])=[CH:26][C:25]=2[F:35])=[CH:19][C:20]=1[C:21]([NH2:23])=[O:22]>>[F:35][C:25]1[CH:26]=[C:27]([C:31]([OH:34])([CH3:33])[CH3:32])[CH:28]=[C:29]([F:30])[C:24]=1[C:18]1[S:17][C:16]([NH:15][C:2]2[CH:3]=[CH:4][C:5]([CH2:9][N:10]3[CH:14]=[CH:13][N:12]=[N:11]3)=[C:6]([CH3:8])[N:7]=2)=[C:20]([C:21]([NH2:23])=[O:22])[CH:19]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526104HCID 59526104, compound

Product 1

HCID 59525957HCID 59525957, compound

Procedure

The title compound was synthesized from 6-chloro-2-methyl-3-(1H-1,2,3-triazol-1-ylmethyl)pyridine (83 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (130 mg, 0.42 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-3c8d08a9dd564d089af5b0fccc256282
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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