2-chloro-6-(1H-1,2,3-triazol-1-yl)pyridine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1H-1,2,3-triazol-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 386057Notes

Reaction equation

HRID 386057 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[N:9]2)[N:3]=1.[NH2:13][C:14]1[S:15][C:16]([C:22]2[C:27]([F:28])=[CH:26][C:25]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:24][C:23]=2[F:33])=[CH:17][C:18]=1[C:19]([NH2:21])=[O:20]>>[F:33][C:23]1[CH:24]=[C:25]([C:29]([OH:32])([CH3:31])[CH3:30])[CH:26]=[C:27]([F:28])[C:22]=1[C:16]1[S:15][C:14]([NH:13][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([N:8]3[CH:12]=[CH:11][N:10]=[N:9]3)[N:3]=2)=[C:18]([C:19]([NH2:21])=[O:20])[CH:17]=1

Participants

3

Reactant 2

HCID 212903442-chloro-6-(1H-1,2,3-triazol-1-yl)pyridineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595257335-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1H-1,2,3-triazol-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was synthesized from 2-chloro-6-(1H-1,2,3-triazol-1-yl)pyridine (72 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-7f3972eaa2694d9dab2ff5ec4f162285
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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