Sodium borohydride → 1-(6-Bromopyridin-2-yl)-1-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethanol

Participants

Reaction Steps

To a solution of NaBH4 (92 mg, 2.42 mmol) in MeOH (3.0 mL) at room temperature was added ethyl{4-[1-(6-bromopyridin-2-yl)-1-hydroxyethyl]-1H-1,2,3-triazol-1-yl}acetate (430 mg, 1.21 mmol) in MeOH (7.0 mL). The reaction was stirred at room temperature for 2 h. It was then diluted with water and extracted with EtOAc (2×) and 5:1 CH2Cl2:MeOH (5×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated. Flash chromatography (0-5% MeOH/EtOAc) afforded the title compound as a colorless solid.

Provenance & Evidence