反应详情

温度

110 °C

(6-Bromopyridin-2-yl)acetonitrile (Example 235, Step 1) (1.00 g, 5.08 mmol), NaN3 (396 mg, 6.09 mmol), and ZnBr2 (1.14 g, 5.08 mmol) were combined in water (10 mL) in a screw-cap vial, sealed, and vigorously stirred at 110° C. for 18 h. The suspension was filtered, and the isolated solid was washed with water to provide the title compound as a colorless solid.

1. customsealed
2. filtrationThe suspension was filtered
3. washthe isolated solid was washed with water