2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59526168, compound

HRID 386079Notes

Reaction equation

HRID 386079 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][C:9]2[N:10]=[N:11][N:12]([CH2:14][CH2:15][OH:16])[N:13]=2)[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[C:31]([F:32])=[CH:30][C:29]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:28][C:27]=2[F:37])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:37][C:27]1[CH:28]=[C:29]([C:33]([OH:36])([CH3:35])[CH3:34])[CH:30]=[C:31]([F:32])[C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][C:9]3[N:10]=[N:11][N:12]([CH2:14][CH2:15][OH:16])[N:13]=3)[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526202HCID 59526202, compound

Product 1

HCID 59526168HCID 59526168, compound

Procedure

The title compound was synthesized from 2-{5-[(6-bromopyridin-2-yl)methyl]-2H-tetrazol-2-yl}ethanol (114 mg, 0.40 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (125 mg, 0.40 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-cf718350c21a4c29bb98cc9d5834fe61
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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