(Morpholin-3-yl)methanol → {4-[(4-Chloropyrimidin-2-yl)methyl]morpholin-3-yl}methanol

HRID 386085Notes

Reaction equation

HRID 386085 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=O)[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH:11]1[CH2:16][OH:17]>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH:11]2[CH2:16][OH:17])[N:3]=1

Participants

3

Reactant 2

HCID 5058360(Morpholin-3-yl)methanolHCID 513419564-Chloropyrimidine-2-carbaldehyde

Product 1

HCID 59525629{4-[(4-Chloropyrimidin-2-yl)methyl]morpholin-3-yl}methanol

Procedure

The title compound was prepared according to the general procedure in Example 45, Step 1 using 4-chloropyrimidine-2-carbaldehyde (0.573 g, 4.02 mmol) and morpholin-3-ylmethanol (0.565 g, 4.82 mmol) as the starting materials.

Sources & evidence

ORD record
ord-a7b407a2cf6243b8b7a3bb4e1c6aaaf9
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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