2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525566, compound

HRID 386087Notes

Reaction equation

HRID 386087 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:22]1[CH:27]=[CH:26][N:25]=[C:24]([CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH:30]2[CH2:35][F:36])[N:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:26]2[CH:27]=[CH:22][N:23]=[C:24]([CH2:28][N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH:30]3[CH2:35][F:36])[N:25]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525671HCID 59525671, compound

Product 1

HCID 59525566HCID 59525566, compound

Procedure

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (26 mg, 0.09 mmol) and 4-[(4-chloropyrimidin-2-yl)methyl]-3-(fluoromethyl)morpholine (21.70 mg, 0.09 mmol) as starting materials.

Sources & evidence

ORD record
ord-0a15591fbafa4d8b8d286458416a35f7
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…