Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-Chloropyrimidine-2-carbaldehyde | HCID 51341956 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-Chloropyrimidin-2-yl)methanol | HCID 55273715 | — |
Reaction Steps
4-Chloropyrimidine-2-carbaldehyde (4.53 g, 31.8 mmol) was taken up in MeOH (65 mL) and cooled to 0° C. NaBH4 (1.262 g, 33.4 mmol) was added and the mixture stirred at 0° C. for 90 minutes. Water was added and the reaction mixture was extracted with CHCl3 (3×).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367706B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-f0996da74fd5490d8922465f1bb9960b |
|---|
| Source note | uspto-grants-2013_02 |
|---|
