(4-Chloropyrimidin-2-yl)methanol → HCID 59525587, compound

HRID 386089Notes

Reaction equation

HRID 386089 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[N:3]=1.[NH2:10][C:11]1[S:12][C:13]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([OH:28])([CH3:27])[CH3:26])=[CH:21][C:20]=2[F:29])=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17]>>[F:29][C:20]1[CH:21]=[C:22]([C:25]([OH:28])([CH3:26])[CH3:27])[CH:23]=[CH:24][C:19]=1[C:13]1[S:12][C:11]([NH:10][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[N:3]=2)=[C:15]([C:16]([NH2:18])=[O:17])[CH:14]=1

Participants

3

Reactant 2

HCID 55273715(4-Chloropyrimidin-2-yl)methanolHCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 59525587HCID 59525587, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using (4-chloropyrimidin-2-yl)methanol (54.0 mg, 0.37 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (100 mg, 0.34 mmol) as the starting materials.

Sources & evidence

ORD record
ord-fa329851c9974e4c92a72f31526fc45f
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…