2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525727, compound

HRID 386091Notes

Reaction equation

HRID 386091 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][F:9])[N:3]=1.[NH2:10][C:11]1[S:12][C:13]([C:19]2[C:24]([F:25])=[CH:23][C:22]([C:26]([OH:29])([CH3:28])[CH3:27])=[CH:21][C:20]=2[F:30])=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17]>>[F:30][C:20]1[CH:21]=[C:22]([C:26]([OH:29])([CH3:28])[CH3:27])[CH:23]=[C:24]([F:25])[C:19]=1[C:13]1[S:12][C:11]([NH:10][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][F:9])[N:3]=2)=[C:15]([C:16]([NH2:18])=[O:17])[CH:14]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525687HCID 59525687, compound

Product 1

HCID 59525727HCID 59525727, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 4-chloro-2-(fluoromethyl)pyrimidine (19.71 mg, 0.13 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (42 mg, 0.13 mmol) as the starting materials.

Sources & evidence

ORD record
ord-cb84e7ebd5164d6cb9bc15926624a1be
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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