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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386102Generated: October 30, 2026

1-(4-Chloropyrimidin-2-yl)pyrrolidin-3-ol → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(3-hydroxypyrrolidin-1-yl)pyrimidin-4-yl]amino}thiophene-3-carboxamide

https://huagongshe.com/reaction/386102

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Chloropyrimidin-2-yl)pyrrolidin-3-olHCID 45787534—
Reactant2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525619—
Product5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(3-hydroxypyrrolidin-1-yl)pyrimidin-4-yl]amino}thiophene-3-carboxamideHCID 59525560—

Reaction Steps

The title compound was prepared according to the general procedure in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide and 1-(4-chloropyrimidin-2-yl)pyrrolidin-3-ol as the starting materials.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08367706B2
Source datasetuspto-grants-2013_02
ORD IDord-70e095253aa4454f961dab6ed549d611
Source noteuspto-grants-2013_02