HCID 43520696, compound → HCID 68670974, compound

HRID 386113Notes

Reaction equation

HRID 386113 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([NH:29][S:30]([N:33]([CH3:35])[CH3:34])(=[O:32])=[O:31])[CH:26]=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([NH:29][S:30]([N:33]([CH3:35])[CH3:34])(=[O:32])=[O:31])[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Participants

3

Reactant 2

HCID 43520696HCID 43520696, compoundHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 68670974HCID 68670974, compound

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) and N′-(6-bromopyridin-2-yl)-N,N-dimethylsulfamide (0.90 g, 0.32 mmol) as the starting materials.

Sources & evidence

ORD record
ord-f1cd47249e114b439ee656aec45ebdc8
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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