2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525646, compound

HRID 386115Notes

Reaction equation

HRID 386115 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH:11]([CH2:15][CH2:16][OH:17])[CH2:10]2)[N:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:29][C:28]=2[F:37])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[F:37][C:28]1[CH:29]=[C:30]([C:33]([OH:36])([CH3:34])[CH3:35])[CH:31]=[CH:32][C:27]=1[C:21]1[S:20][C:19]([NH:18][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][N:9]3[CH2:14][CH2:13][O:12][CH:11]([CH2:15][CH2:16][OH:17])[CH2:10]3)[N:3]=2)=[C:23]([C:24]([NH2:26])=[O:25])[CH:22]=1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59526309HCID 59526309, compound

Product 1

HCID 59525646HCID 59525646, compound

Procedure

The title compound was prepared as described in Example 106, Step 2 with 2-{4-[(4-chloropyrimidin-2-yl)methyl]morpholin-2-yl}ethanol (50 mg, 0.19 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (57 mg, 0.19 mmol) as starting materials.

Sources & evidence

ORD record
ord-b1232aec5924430291e96f80437d5975
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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