HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386116Generated: October 30, 2026
2-Methyl-3-butyn-2-ol → HCID 59526350, compound
https://huagongshe.com/reaction/386116
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methyl-3-butyn-2-ol | HCID 8258 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3,6-Dichloropyridazine | HCID 67331 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59526350 | HCID 59526350 | — |
Reaction Steps
To a solution of 3,6-dichloropyridazine (250 mg, 1.68 mmol) and 2-methylbut-3-yn-2-ol (282 mg, 3.36 mmol) in DMF (4 mL) were added CuI (64 mg, 0.33 mmol), triethylamine (0.47 mL, 3.36 mmol), and palladium tetrakis triphenylphosphine (194, 0.168 mmol). The solution was degassed and heated to 80° C. overnight. The residue was worked up with EtOAc and water, dried with MgSO4, filtered, and concentrated. Column chromatography on silica gel 100% Hex to 100% EtOAc provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367706B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-3b8b45aa30624347b51a7afcd576436e |
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| Source note | uspto-grants-2013_02 |
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