3,6-Dichloropyridazine → HCID 59525729, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,6-dichloropyridazine (250 mg, 1.68 mmol) and [(1E)-3-hydroxy-3-methylbut-1-en-1-yl]boronic acid (218 mg, 1.68 mmol) in THF (5 mL) and 2.0 M NaHCO3 (1.70 mL) was added palladium tetrakis triphenylphosphine (97 mg, 0.084 mmol). The solution was degassed with nitrogen and heated to 85° C. overnight. The residue was worked up with EtOAc and water, dried with MgSO4, filtered, and concentrated. Column chromatography on silica gel 100% Hex to 100% EtOAc provided the title compound.

Provenance & Evidence