HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 58216638 | — |
| Reactant | 2-(6-Chloropyridazin-3-yl)propan-2-ol | HCID 59526161 | — |
| Product | 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide | HCID 59525859 | — |
Reaction Steps
The title compound was prepared by using the procedure listed in Example 1 with starting materials 2-(6-chloropyridazin-3-yl)propan-2-ol (Intermediate 45) (117 mg, 0.68 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.68 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-9c87e8e43b5343138ba63c401fc048ec |
| Source note | uspto-grants-2013_02 |