HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperidine → Tert-butyl[3-cyano-5-(6-piperidin-1-ylpyridin-3-yl)-2-thienyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]piperidine | HCID 16414210 | — |
| Reactant | Tert-butyl(3-cyano-5-iodo-2-thienyl)carbamate | HCID 70842571 | — |
| Product | Tert-butyl[3-cyano-5-(6-piperidin-1-ylpyridin-3-yl)-2-thienyl]carbamate | HCID 70842611 | — |
Reaction Steps
The title compound was prepared from tert-butyl(3-cyano-5-iodo-2-thienyl)carbamate (Example 581 Step 2) (500 g, 1.43 mmol) and 2-piperidin-1-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (658 mg, 2.29 mmol) as described in Example 581, Step 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d2e58d04a5414231bc78e1fae6e7c238 |
| Source note | uspto-grants-2013_02 |