2-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol → 2-{[6-(2-Hydroxy-1-morpholin-4-ylethyl)pyridine-2-yl]amino}-5-(6-piperidin-1-ylpyridin-3-yl)thiophene-3-carboxamide

HRID 386138Notes

Reaction equation

HRID 386138 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:11]=[N:12][C:13]([N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:14][CH:15]=2)=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([CH:29]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH2:30][OH:31])[CH:26]=[CH:25][CH:24]=1>>[OH:31][CH2:30][CH:29]([C:27]1[N:28]=[C:23]([NH:1][C:2]2[S:3][C:4]([C:10]3[CH:11]=[N:12][C:13]([N:16]4[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]4)=[CH:14][CH:15]=3)=[CH:5][C:6]=2[C:7]([NH2:9])=[O:8])[CH:24]=[CH:25][CH:26]=1)[N:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 583352752-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanolHCID 595260802-Amino-5-(6-piperidin-1-ylpyridin-3-yl)thiophene-3-carboxamide

Product 1

HCID 595257402-{[6-(2-Hydroxy-1-morpholin-4-ylethyl)pyridine-2-yl]amino}-5-(6-piperidin-1-ylpyridin-3-yl)thiophene-3-carboxamide

Procedure

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-(6-piperidin-1-ylpyridin-3-yl)thiophene-3-carboxamide (70 mg, 0.23 mmol) and 2-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanol (Example 141, Step 1) (66 mg, 0.23 mmol) as the starting materials.

Sources & evidence

ORD record
ord-00fb0baff0bb4048bfa300815c385be7
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…