(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → HCID 58116984, compound

HRID 38615Notes

Reaction equation

HRID 38615 reaction equation
Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[C:6]([NH:10][C:11]2[C:12]3[C:19]4[CH2:20][CH2:21][NH:22][CH2:23][C:18]=4[S:17][C:13]=3[N:14]=[CH:15][N:16]=2)=[CH:5][C:4]=1[OH:24].Cl.[CH3:26][N:27]([CH3:34])[CH2:28]/[CH:29]=[CH:30]/[C:31](O)=[O:32]>>[CH3:26][N:27]([CH3:34])[CH2:28]/[CH:29]=[CH:30]/[C:31]([N:22]1[CH2:21][CH2:20][C:19]2[C:12]3[C:11]([NH:10][C:6]4[C:7]([F:9])=[CH:8][C:3]([F:2])=[C:4]([OH:24])[CH:5]=4)=[N:16][CH:15]=[N:14][C:13]=3[S:17][C:18]=2[CH2:23]1)=[O:32]

Participants

3

Reactant 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 668499002,4-Difluoro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

Product 1

HCID 58116984HCID 58116984, compound

Procedure

The compound was synthesized in analogy to Example 122 from 2,4-difluoro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 71A (100 mg, 0.27 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (63 mg, 0.38 mmol) to yield 40 mg (32%).

Workup

  1. customto yield 40 mg (32%)

Sources & evidence

ORD record
ord-44264225071e46b2b14ad467f5a1d9c5
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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