HCID 66849855, compound → N-(3,4-Dichlorophenyl)-6-{(2E)-4-[methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

HRID 38617Notes

Reaction equation

HRID 38617 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][NH:20][CH2:21][CH2:22][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:24][N:25]([CH:32]([CH3:34])[CH3:33])[CH2:26]/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][N:20]([C:29](=[O:30])/[CH:28]=[CH:27]/[CH2:26][N:25]([CH3:24])[CH:32]([CH3:34])[CH3:33])[CH2:21][CH2:22][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 66849855HCID 66849855, compoundHCID 86650197(2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride

Product 1

HCID 58116894N-(3,4-Dichlorophenyl)-6-{(2E)-4-[methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

Procedure

The title compound was synthesized in analogy to Example 89 from N-(3,4-dichlorophenyl)-5,6,7,8-tetrahydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 76A (100 mg, 0.29 mmol) and (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride from Example 2A (77 mg, 0.40 mmol) to yield 56 mg (40%).

Workup

  1. customto yield 56 mg (40%)

Sources & evidence

ORD record
ord-b856ce1bf2d94008be30285146c297cd
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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