4-Bromocrotonic acid → HCID 25222663, compound

Participants

Reaction Steps

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (85 mg, 0.41 mmol), N-(3,4-dichlorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5′,4′:4,5]thieno[2,3-c]azepin-4-amine from Example 82A (100 mg, 0.27 mmol) and 1,4-oxazepane hydrochloride (60 mg, 0.44 mmol) to yield 41 mg (26%).

Provenance & Evidence