N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]-azepin-4-amine → N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-8-{(2E)-4-[methyl(1-methylethyl)amino]but-2-enoyl}-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]azepin-4-amine

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 89 from N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5′,4′:4,5]thieno[2,3-c]azepin-4-amine from Example 83A (100 mg, 0.23 mmol) and (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride from Example 2A (61 mg, 0.32 mmol) to yield 39 mg (29%).

Provenance & Evidence