(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → N-(3-Chloro-4-fluorophenyl)-7-[(2E)-4-(dimethylamino)but-2-enoyl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine

Participants

Reaction Steps

The title compound was prepared in analogy to Example 89 from N-(3-chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5′,4′:4,5]thieno[2,3-d]azepin-4-amine from Example 85A (100 mg, 0.29 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (66 mg, 0.40 mmol) to yield 89 mg (67%).

Provenance & Evidence