HRID386306

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：Cc1ccc(S(=O)(=O)OC[C@H]2C[C@@H](c3ncc4c(Cl)nccn43)C2)cc1

HCID178427764

未命名化合物

HCID178427765

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OC[C@H]1C[C@@H](c2ncc3c(Cl)nccn32)C1

HCID178455229

未命名化合物

HCID178455230

未命名化合物

PROCEDURE

实验过程

cis-3-[3-(tert-Butyldimethylsilanyloxymethyl)cyclobutyl]-8-chloroimidazo[1,5-a]pyrazine and trans-3-[3-(tert-butyldimethylsilanyloxymethyl)cyclobutyl]-8-chloroimidazo[1,5-a]pyrazine were prepared according to the general procedure for the preparation for cis-3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutylmethyl toluene-4-sulfonate and trans-3-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutylmethyl toluene-4-sulfonate, except tert-butylchlorodimethylsilane was used instead of p-toluenesulfonic anhydride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b20cfade333547409138c99f3782b8d2
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367826B2
来源说明: uspto-grants-2013_02

反应 SMILES

C1(C)C=CC(S([O:10][CH2:11][C@H:12]2[CH2:15][C@@H:14]([C:16]3[N:20]4[CH:21]=[CH:22][N:23]=[C:24]([Cl:25])[C:19]4=[CH:18][N:17]=3)[CH2:13]2)(=O)=O)=CC=1.C1(C)C=CC(S([O:36][CH2:37][C@H:38]2[CH2:41][C@H:40]([C:42]3[N:46]4[CH:47]=[CH:48][N:49]=[C:50]([Cl:51])[C:45]4=[CH:44][N:43]=3)[CH2:39]2)(=O)=O)=CC=1.[C:53]([Si:57](Cl)([CH3:59])[CH3:58])([CH3:56])([CH3:55])[CH3:54]>>[Si:57]([O:10][CH2:11][C@@H:12]1[CH2:13][C@H:14]([C:16]2[N:20]3[CH:21]=[CH:22][N:23]=[C:24]([Cl:25])[C:19]3=[CH:18][N:17]=2)[CH2:15]1)([C:53]([CH3:56])([CH3:55])[CH3:54])([CH3:59])[CH3:58].[Si:57]([O:36][CH2:37][C@H:38]1[CH2:39][C@H:40]([C:42]2[N:46]3[CH:47]=[CH:48][N:49]=[C:50]([Cl:51])[C:45]3=[CH:44][N:43]=2)[CH2:41]1)([C:53]([CH3:56])([CH3:55])[CH3:54])([CH3:59])[CH3:58]