反应详情

温度

25 °C

To a solution of 16 (0.2 g, 0.67 mmol) in CH2Cl2 (3 mL) was added 5 mL of BCl3 solution (1 M in CH2Cl2) dropwise at 0°±1° C. The mixture was stirred at 25±1° C. for 2 h and then poured into crushed ice, extracted with EtOAc. The organic layer was washed with H2O, dried over MgSO4 and evaporated. The crude was purified by column chromatography (SiO2, CHCl3: MeOH=15:1) and recrystallized from MeOH to give 37. Yellow solid; yield: 24.1%; mp 268-270° C.; MS (EI, 70 eV): m/z 285 (M+); IR (KBr): 1604.77 (C═O) cm−1; 1H-NMR (DMSO-d6. 200 MHz): δ 3.78 (s, 3H), 6.11 (s, 1H), 7.01 (d, J=7.4 Hz, 1H), 7.36-7.48 (m, 3H), 7.54-7.72 (m, 2H), 12.25 (s, 1H), 14.54 (s, 1H); 13C-NMR (DMSO-d6, 50 MHz): δ 55.80, 106.22, 106.43, 112.88, 116.36 (d, J=23 Hz), 120.81, 121.96 (d, J=13.5 Hz), 125.04, 130.85, 132.67 (d, J=8.6 Hz), 135.09, 141.02, 146.27, 149.29, 158.92 (d, J=247.7 Hz), 181.97; Anal. calcd for C16H12FNO3: C, 67.36; H, 4.24; N, 4.91. Found: C, 67.32; H, 4.26; N, 4.89.

1. additionpoured
2. custominto crushed ice
3. extractionextracted with EtOAc
4. washThe organic layer was washed with H2O
5. dry with materialdried over MgSO4
6. customevaporated
7. customThe crude was purified by column chromatography (SiO2, CHCl3: MeOH=15:1)
8. customrecrystallized from MeOH