Methacrylic Acid → 4-Propyl-cyclohexanecarboxylic acid 4-(2-methyl-acryloyloxy)-butyl ester

Participants

Reaction Steps

4-Propyl-cyclohexanecarboxylic acid 4-bromo-butyl ester (9.4 g, 30.8 mmol), methacrylic acid (8.0 g, 92.4 mmol) and potassium carbonate (17.0 g, 123.2 mmol) are stirred at 50° C. in dimethyl sulphoxide (200 ml) over night. A solid precipitate is removed by filtration and washed with diethyl ether. The filtrate is washed with water, removed, dried and evaporated to dryness. Purification is achieved by flash column chromatography using toluene as eluant to give 21 as an oil.

Provenance & Evidence