8-(2-Dimethylamino-4-nitro-phenyl)purin-6-one → 8-(4-Amino-2-dimethylamino-phenyl)purin-6-one

HRID 3864Notes

Reaction equation

HRID 3864 reaction equation
[CH3:1][N:2]([CH3:22])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[N:20]=[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]2=[O:21])[N:13]=1.[H][H]>CO.[Ni]>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[N:20]=[C:19]3[C:14](=[N:15][CH:16]=[N:17][C:18]3=[O:21])[N:13]=2)=[C:3]([N:2]([CH3:22])[CH3:1])[CH:8]=1

Participants

5

Reactant 2

HCID 201532228-(2-Dimethylamino-4-nitro-phenyl)purin-6-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 201532408-(4-Amino-2-dimethylamino-phenyl)purin-6-one

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

An amount of 0.9 gm of 8-(2-dimethylamino-4-nitro-phenyl)purin-6-one is hydrogenated in 50 ml of methanol in the presence of 0.5 gm of Raney nickel at ambient temperature and under 5 bars of pressure with hydrogen for three hours until the calculated quantity has been taken up. After the catalyst has been subjected to suction filtration, the filtrate is evaporated to dryness in vacuo.

Workup

  1. filtrationAfter the catalyst has been subjected to suction filtration
  2. customthe filtrate is evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-7272044c980b48afb3322c501ec35ccc
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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