HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386403Generated: October 29, 2026
Thionyl Chloride → 5-Bromofuran-2-carbohydrazide
https://huagongshe.com/reaction/386403
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Bromo-2-furanecarboxylic acid | HCID 68511 | — |
| Reactant | 5-Bromofuran-2-carbonyl chloride | HCID 2757011 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromofuran-2-carbohydrazide | HCID 468636 | — |
Reaction Steps
A mixture of 5-bromo-furan-2-carboxylic acid (38.2 g, 200 mmol) and thionylchloride (163.1 g, 1.37 mol) was stirred at 70° C. overnight. The mixture of 5-bromo-furan-2-carbonyl chloride was evaporated, solved in tetrahydrofuran (10 ml) and added to a mixture of hydrazine monohydrate (120.1 g, 2.4 mol), followed by stirring for 0.5 hours at <5° C. Water (50 ml) was added followed by filtration. The crystalline product was recrystallized from ethanol (125 ml, 96%). Yield 21.2 g (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08372832B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-2f6b5d70394a4929a29fc8f00d8ab132 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
