Boron tribromide → HCID 135616893, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-1,4-diaza-bicyclo[3.2.2]nonane (1.0 g, 3.3 mmol) and chloroform (20 ml) was cooled to −63° C. A mixture of boron tribromide (5.4 g, 21.6 mmol) and chloroform (10 ml) was added at 60° C. The mixture was allowed to reach room-temperature. The crude mixture was purified by column chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent and gave the title compound. LC-ESI-HRMS of [M+H]+ shows 287.1514 Da. Calc. 287.150801 Da, dev. 2.1 ppm.

Provenance & Evidence