Morpholine → HCID 46182231, compound

Participants

Reaction Steps

A solution of N-benzyl-N-(3-bromo-phenyl)-benzene sulfonamide (25 mg, 0.06 mmol), morpholine (6.5 μl, 0.07 mmol), palladium acetate (1 mg), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (2 mg) and sodium tert-butoxide (21 mg, 0.22 mmol) in dioxane (1 ml) were heated to 100° C. in the microwave for 30 minutes. The reaction was filtered, diluted with water (5 ml) and extracted with dichloromethane (3×6 ml). The combined organics were filtered, concentrated in vacuo and the residues purified by preparative TLC (eluent dichloromethane) to afford the title compound as a yellow solid (18 mg, 71%) HPLC retention time 8.3 min. Mass spectrum (ES+) m/z 409 (M+H).

Provenance & Evidence