1-Phenylpiperazine → HCID 46182230, compound

Participants

Reaction Steps

A solution of N-benzyl-N-(3-bromo-phenyl)-benzene sulfonamide (25 mg, 0.06 mmol), 1-phenyl-piperazine (0.011 ml, 0.074 mmol), palladium acetate (1 mg), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (2 mg) and sodium tert-butoxide (21 mg, 0.22 mmol) in dioxane (4 ml) were refluxed overnight. The reaction was quenched with water (5 ml) and extracted with dichloromethane (3×6 ml). The organic extracts were combined, filtered then concentrated in vacuo and the residues purified by preparative TLC (SiO2) eluting with dichloromethane to afforded the title compound as a yellow solid (23 mg, 77%) HPLC retention time 9.4 min. Mass spectrum (ES+) m/z 484 (M+H).

Provenance & Evidence