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HRID 386528作成日：2026年10月25日
1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine → (2S)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid
https://huagongshe.com/reaction/386528
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine | HCID 667618 | — |
| 反応物 | (2R)-2-Bromopropanoic acid | HCID 6992152 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2S)-2-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanoic acid | HCID 66628464 | — |
反応手順
A solution of 1-(5-trifluoromethyl-pyridin-2-yl)-piperazine (2.77 g, 11.99 mmoles) in DCM (42 mL) and TEA (4.2 mL) was treated with (2R)-2-bromo-propionic acid (1.19 mL, 13.2 mmoles) and stirred overnight at 35° C. The DCM was removed under reduced pressure to provide crude title compound as a yellowish solid that was used in the next step. MS(APCI+) m/z 304 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08372841B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-d7a3a3a4e5fa4375861b0c7d2c02bfee |
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| 出典メモ | uspto-grants-2013_02 |
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