反应详情

4.45 g (0.0174 mmol) of methyl 3-(benzyloxy)-5-methoxybenzoate (161) was suspended in 120 mL of 95% ethanol and 5 mL water. An amount of 2.00 g (0.05 mmol) of sodium hydroxide was added. The mixture was heated at reflux for 1 h. After the mixture was evaporated, the residue was quenched with 150 mL of water. The solution was neutralized with dil aq HCl and then the precipitate was collected and washed with water and acetone to give 162.

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 h
3. customAfter the mixture was evaporated
4. customthe residue was quenched with 150 mL of water
5. customthe precipitate was collected
6. washwashed with water and acetone