HRID386574

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1nn(-c2ccc(Br)cc2F)c(=O)cc1OC1CCN(C(=O)OC(C)(C)C)CC1

HCID44621138

未命名化合物

结构：CS(=O)(=O)c1ccc(-n2nc(C(=O)[O-])ccc2=O)cc1

HCID86658658

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2cc(=O)n(-c3ccc(Br)cc3F)nc2C(N)=O)CC1

HCID67445269

未命名化合物

收率 100%

PROCEDURE

实验过程

tert-Butyl 4-(1-(4-bromo-2-fluorophenyl)-3-carbamoyl-6-oxo-1,6-dihydropyridazin-4-yloxy)piperidine-1-carboxylate was prepared in 100% yield according to procedures described in Example 31 (Step A) substituting methyl 441-(tert-butoxycarbonyl)piperidin-4-yloxy)-1-(4-(methylsulfonyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate for Methyl 1-(4-bromo-2-fluorophenyl)-4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)-6-oxo-1,6-dihydropyridazine-3-carboxylate (Example 44). MS (ESI) 511 (M+H).