HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(6-Amino-1,3-benzodioxol-5-yl)ethan-1-one | HCID 120000 | — |
| Reactant | 3-(Benzyloxy)-5-methoxybenzoyl chloride | HCID 12658783 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide | HCID 58052627 | — |
Reaction Steps
Into solutions of 163 (2.77 g, 0.01 mmol) in 200 mL of dry tetrahydrofuran were added triethylamine (10 mL) and 2-amino-4,5-methylenedioxy acetophenone (148) (1.79 g, 0.01 mmol). The mixtures were stirred at room temperature for 24 h and then evaporated. The residue was purified by column chromatography (SiO2, CH2Cl2/EtOAc=3/1) to give 164.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524740B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-c239a359c16f4968aa3d81de3e877c11 |
| Source note | uspto-grants-2013_09 |