Sodium Iodide → HCID 86638335, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing 5-methyl-1H-pyrazol-3-amine 187 mg, 1.93 mmol), N,N-diisopropylethylamine (503 μl, 2.89 mmol), sodium iodide (289 mg, 1.93 mmol) and DMF (50 mL) was treated with 4,6-dichloro-2-(2-chlorophenyl)pyrimidine (500 mg, 1.93 mmol). The reaction mixture was then heated at 110° C. for 48 h before being cooled to room temperature and concentrated in vacuo. The resulting residue was purified by column chromatography (eluting with MeOH/DCM, 5/95) to give the title compound as a solid (433 mg, 70%). MS (ES+) m/e=320. 1H NMR: (DMSO) 2.18-2.23 (3H, m), 7.40-7.70 (6H, m), 10.32 (1H, s), 12.10 (1H, brs)

Provenance & Evidence