HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 386599Generated: October 31, 2026
Triethylamine → 4-Chloro-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline
https://huagongshe.com/reaction/386599
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-7-methoxy-3H-quinazolin-4-one | HCID 135991777 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Chloro-6-(1,4-dioxa-spiro[4,5]decan-8-yl-oxy)-7-methoxy-quinazoline | HCID 59158225 | — |
Reaction Steps
6 ml phosphorus oxychloride are added dropwise to 12.1 g of 3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline in 120 ml acetonitrile and the mixture is heated to an internal temperature of 40° C. Then 9.3 ml triethylamine are added dropwise and the reaction mixture is refluxed for 3 hours. The mixture is cooled to ambient temperature and left to stand overnight. The solution of the product is reacted further without purification (see Example III).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08372855B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-7df02082561e43a7815491c9d2b3b4d4 |
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| Source note | uspto-grants-2013_02 |
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