Potassium Hydroxide → 8-(4-Benzyloxy-2-methoxy-phenyl)-purin-6-one

HRID 3866Notes

Reaction equation

HRID 3866 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[NH:23][C:22]3[C:17](=[N:18][CH:19]=[N:20][C:21]=3Cl)[N:16]=2)=[C:11]([O:25][CH3:26])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:27].[K+]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:23]=[C:22]3[C:17](=[N:18][CH:19]=[N:20][C:21]3=[O:27])[N:16]=2)=[C:11]([O:25][CH3:26])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 201532198-(4-Benzyloxy-2-methoxy-phenyl)-6-chloro-purine

Product 1

HCID 201533328-(4-Benzyloxy-2-methoxy-phenyl)-purin-6-one

Procedure

Prepared analogously to Example 16 from 8-(4-benzyloxy-2-methoxy-phenyl)-6-chloro-purine by reaction with 40% potassium hydroxide solution.

Sources & evidence

ORD record
ord-7c71ace40aec4481bedb5ae26a19e76f
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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