Sulfuric Acid → N-(2-(6-chloropyridin-3-yl)propan-2-yl)acetamide

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Reaction Steps

A solution of the product from Step A, 1-A, (33.42 g, 195 mmol) in CH3CN (250 mL) was cooled to 0° C. using an ice-water bath. Sulfuric acid (72.7 mL, 1363 mmol) was slowly added and the reaction mixture was allowed to warm to rt and was stirred between 48-72 h. The reaction mixture was cooled to 0° C. using an ice-water bath, diluted with H2O (100 mL) and subsequently treated slowly with aq. 29% NH4OH (203 mL). The quenched mixture was extracted with MTBE and the organic layer was separated. The aqueous layer was extracted with MTBE and the combined organic layers were concentrated under reduced pressure until a solid was present. The solids were treated with hexanes, collected by vacuum filtration and dried under high vacuum. HPLC/MS: 213.0 (M+1); Rt=1.71 min.

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