HCID 57747428, compound → HCID 57747432, compound

Participants

Reaction Steps

tert-Butyl 4-(2,6-dimethyl-4-(pyridin-4-yl)phenylthio)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-2-yl4-cyanophenylcarbamate is treated with TFA (10 mL) at 25° C. for 2 h. TFA is removed and the obtained residue dissolved in ethyl acetate, and extracted with saturated aqueous NaHCO3 (×2). The organic layer is collected, concentrated, and the purified by chromatography (SiO2, 1:4 hexanes/EtOAc).

Provenance & Evidence