4-Methyl-6-nitro-2H-1,4-benzoxazin-3-one → 6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

Participants

Reaction Conditions

Reaction Steps

Fe powder (4.1 g, 73.20 mmol) was added to a solution of 4-methyl-6-nitro-4H-benzo[1,4]oxazin-3-one (3.0 g, 14.42 mmol) in EtOH (100 ml) and water (50 ml). The mixture was stirred at 60° C. vigorously with a mechanic stirrer for 18 hours, then filtered through a celite cake. The filtrate was concentrated under reduced pressure to give 2.50 g of 6-amino-4-methyl-4H-benzo[1,4]oxazin-3-one as a solid, 98%.

Provenance & Evidence