HCID 66845663, compound → HCID 66845127, compound

HRID 386676Notes

Reaction equation

HRID 386676 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:23])[CH3:22])=[CH:16][C:11]=3[C:12](=[O:15])[C:13]=2[OH:14])=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.CO>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:23])[CH3:22])=[CH:16][C:11]=3[C:12](=[O:15])[C:13]=2[O:14][CH2:8][C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 66845663HCID 66845663, compound

Product 1

HCID 66845127HCID 66845127, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Prepared analogously to Example 5d, starting from 2-(4-hydroxyphenyl)-3-hydroxy-6-acetamido-4H-1-benzopyran-4-one. Yield: 84%; Rf (9/1 Chloroform/Methanol): 0.59, 1H-NMR (d6-DMSO): 10.38 (s broad, 1H), 8.40 (d, 1H), 8.1-7.9 (m, 3H), 7.70 (d, 1H); 7.55-7.25 (m, 10H); 7.17 (d, 2H); 5.22 (s, 2H), 5.07 (s, 2H); 2.11 (s, 3H).

Workup

  1. customPrepared analogously to Example 5d

Sources & evidence

ORD record
ord-6da7edeecbd149378cedbd220c04ad87
Source dataset
uspto-grants-2013_02
Patent number
US08372866B2

Reaction notes

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